Ep. 47: How Machine Learning Models Find Undruggable Targets with Alex Federation

In this episode, VibeCast host Ray Dogum speaks with Dr. Alex Federation, Co-Founder and CEO of Talus Bioscience, about leveraging machine learning to unlock the potential of the undruggable genome for groundbreaking therapies. ----------------------------------------------------- Key moments: 00:00:06 - Introduction to Vibecast 00:01:01 - Background and Early Inspiration 00:05:55 - Tackling the Undruggable Genome 00:09:14 - Specific Work in the Pipeline 00:13:26 - Leveraging AI in Biotech 00:15:09 - Using Machine Learning for Drug Development 00:16:40 - Leveraging Epigenome Profiling Data 00:17:18 - Seeking Partnerships for Drug Development 00:18:53 - Current Fundraising and Biotech Economy 00:21:33 - Tackling the Undruggable Problem Guest Bio: Alex Federation, Ph.D. is the co-founder and CEO of Talus Bio. Dr. Federation invented the MARMOT platform during his postdoctoral fellowship at the Altius Institute for Biomedical Research in Seattle where he trained in computational epigenomics and cancer biology with John Stamatoyannopoulos and Fyodor Urnov. Prior to that, Dr. Federation received his Ph.D. in chemical biology from Harvard, training with Jay Bradner in drug development for genome regulators. Guest Links: Linkedin: https://www.linkedin.com/in/afederation/ Talus Bio Twitter: https://twitter.com/talusbio Talus Bio Website: https://talus.bio/ About VibeCast VibeCast is our weekly informational podcast and content series exploring the hottest topics in drug development and Web3 with some of the dynamic people that make up the Vibe community. VibeCast is a collection of long-form and short-form video content intended to help our community learn about the current opportunities and challenges in biotech fundraising and community engagement innovation. Guests include biotech founders, regulatory experts, drug development executives, blockchain technologists, web3 community builders, patient community advocates, and many other Vibe Bio community members seeking to accelerate the development of breakthrough treatments. Follow Vibe Bio's Socials: https://twitter.com/VibeBio https://www.linkedin.com/company/vibe-bio/ https://www.instagram.com/vibebiotechnology/ https://www.tiktok.com/@vibebio https://www.facebook.com/VibeBiotechnology/ Disclaimer: VibeCast is intended to be used for educational and entertainment purposes, and no information or opinions shared constitute advice or services. While guests are invited to listen, listeners acknowledge they are not being provided professional advice from the podcast or the guests. The podcast is for private non-commercial use and the statements of our guests reflect their personal views only and do not necessarily reflect the views or positions of any agency, organization, or company that they work for or are affiliated with.