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In this episode, VibeCast host Ray Dogum speaks with Travis Stiles, PhD, CEO of Novoron Biosciences, about Uncovering Protein Dysregulation in Neurodegenerative Disease. -------------------------------------------------------- Key moments: 00:00:00 - Introduction 00:01:14 - Career Shift to Neuroscience 00:05:19 - Founding Novoron Biosciences 00:09:07 - Drug Development Focus 00:11:53 - Clinical Studies and Drug Pipeline 00:13:07 - Understanding Alzheimer's Disease Components 00:14:08 - Targeting Amyloid and Tau Pathology 00:15:51 - Precision Drug Discovery for Tauopathy 00:17:44 - Route of Administration and Modality 00:22:28 - Strategic Partnerships and Collaborations 00:26:09 - Exploring New Frontiers in Biotech 00:27:05 - Advancements in Spinal Cord Therapy 00:27:47 - Ethical Concerns in Brain-Computer Interfaces 00:29:46 - Integration of Technologies in Biotech 00:32:08 - The Entrepreneurial Journey in Biotech Guest Bio: For more than a decade, Dr. Travis Stiles has studied the mechanisms underlying regenerative failure in the CNS. His work led to the discovery that the LRP1 receptor was a novel therapeutic target for neuronal regeneration after CNS damage or disease. To best translate his work into viable therapies, Dr. Stiles co-founded Novoron Bioscience early in 2014. Novoron's work developing drugs against LRP1 has opened the door to the discovery of an entirely new class of drugs capable of targeting LRP1 and other members of the low-density lipoprotein receptor family, which play critical roles in multiple diseases, but have been long considered untargetable by conventional means. Dr. Stiles holds a PhD in Biomedical Science from the University of California, San Diego (UCSD). His outstanding contributions have earned him recognition as a top innovator by esteemed groups such as J&J and Biocom, along with over $3 million in federal grants. Additionally, Dr. Stiles has actively served on multiple scientific review boards for the National Institute of Health and recently completed a four-year Federal Advisory Committee appointment to the Scientific Merit Review Board subcommittee for Regenerative Medicine in the Department of Veterans Affairs. Guest Links: Linkedin: http://www.linkedin.com/in/travis-stiles-00812a23 Twitter: https://twitter.com/titostiles Novoron Biosciences Twitter: https://twitter.com/NovoronBio Novoron Biosciences Linkedin: https://www.linkedin.com/company/novoron-bioscience/ Novoron Biosciences Website: https://novoron.com/ About VibeCast VibeCast is our weekly informational podcast and content series exploring the hottest topics in drug development and Web3 with some of the dynamic people that make up the Vibe community. VibeCast is a collection of long-form and short-form video content intended to help our community learn about the current opportunities and challenges in biotech fundraising and community engagement innovation. Guests include biotech founders, regulatory experts, drug development executives, blockchain technologists, web3 community builders, patient community advocates, and many other Vibe Bio community members seeking to accelerate the development of breakthrough treatments. Follow Vibe Bio's Socials: https://twitter.com/VibeBio https://www.linkedin.com/company/vibe-bio/ https://www.instagram.com/vibebiotechnology/ https://www.tiktok.com/@vibebio https://www.facebook.com/VibeBiotechnology/ Disclaimer: VibeCast is intended to be used for educational and entertainment purposes, and no information or opinions shared constitute advice or services. While guests are invited to listen, listeners acknowledge they are not being provided professional advice from the podcast or the guests. The podcast is for private non-commercial use and the statements of our guests reflect their personal views only and do not necessarily reflect the views or positions of any agency, organization, or company that they work for or are affiliated with.
